Nitrogen heterocycles are an important class of compounds because of their highly potent medicinal activities, and the imidazole subcategory is of special interest in regards to drug discovery research. An expeditious synthetic protocol of 2,4(1H)-diarylimidazoles has been accomplished by reacting phenylglyoxal monohydrate, ammonium acetate and aldehyde under sonication. Following this newly developed green approach a series of 2,4(1H)-diarylimidazoles has been synthesized using diversely substituted aldehydes, ammonium acetate/amines and phenylglyoxal monohydrate.  Other salient features of this protocol include milder conditions, atom-economy, easy extraction, and no wastes. The structure of the compounds was elucidated by various spectroscopic methods and a plausible mechanistic pathway has been suggested. The present procedure is equally effective for N-polyaromatic substituted amines and will find application in the synthesis of potent biologically active molecules.

Ultrasound-assisted green approach toward substituted 2,4(1H)-diarylimidazoles

246th National Meeting (2013)

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