Nickel catalyzed C-H activation and C-C bonds formation using C-O electrophiles is very desirable from both economical and environmental standpoints. The nickel-catalyzed intramolecular C-H arylation using aryl pivalates as electrophiles is described. The transformation can be applied to a number of electronically- and sterically-differentiated diaryl ether substrates to afford dibenzofurans. Mechanistic studies show similarities to Pd-catalyzed intramolecular C-H arylations that are believed to proceed via concerted metallation-deprotonation pathway.

Nickel-catalyzed C-H arylation using C-O electrophiles

246th National Meeting (2013)

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