Hydrofunctionalization of olefinic substrates represents a significant challenge in transition metal-mediated reactions. To this end, ongoing investigations conducted with nucleophiles on olefinic substrates to determine reactivity of various alkenes and the regioselectivity of the product are being conducted. Substrates with the ability to bias the olefin functionalization step have been studied for their capability to control the regioselectivity of various hydrofunctionalization reactions. A wide range of studies were also conducted to determine the effect of steric and electronic modifications to both the alkene and the nucleophile on the reaction. The proposed hydrofunctionalization reaction involves (1) oxidative addition into the X�H bond, (2) substrate coordination, (3) olefin insertion into the [M]�X bond, and finally, (4) reductive elimination of the C�H bond, generating the product and regenerating the catalyst. This poster will discuss both the stoichiometric and catalytic studies that have been undertaken in developing late transition metal-catalyzed hydrofunctionalization reactions.

Late transition metal-mediated hydrofunctionalization of olefinic substrates

246th National Meeting (2013)

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