We have been looking at the synthesis of substituted chalcones and their cytotoxic activity toward certain cancer cells. Chalcones containing nitro groups in both rings required use of methanesulfonic acid as catalyst and solvent. We have extended this protocol to the synthesis of chalcones based on pyridinecarboxaldehyde and acetylpyridine isomers. We had looked at this several years ago but wanted to relook at it incorporating other synthetic methods. The pi-deficient nature of the pyridine ring again required the use of methanesulfonic acid like their nitro counterparts.  We have not isolated pyridyl chalcones but rather the corresponding ketols. Their evaluation for cytotoxic properties will also be reported.

Synthesis of chalcones from acetylpyridine and pyridine carboxaldehyde isomer combinations and their evaluation for cytotoxic activity

247th National Meeting (2014)

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