Catalytic functionalization of unactivated sp3-hybridizedC-H bonds in the absence of directing groups is highly desirable, but remains challenging. The level difficulty of these functionalizations increases dramatically when regio- and chemoselectivity issues are introduced.  Herein, we disclose the first metal-catalyzed C(sp3)-H arylation of unactivated allyl benzenes (pKa = 34 in DMSO solvent) with arylbromides to afford 1,1-diaryl-2-propenes. A base/catalyst combination was identified that efficiently promotes the DCCP of allylbenzenes in good to excellent yields (55�97%).

Chemo- and regioselective C(sp<sup>3</sup>)-H arylation of unactivated allylarenes via a deprotonative cross-coupling process

247th National Meeting (2014)

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Chemo- and regioselective C(sp3)-H arylation of unactivated allylarenes via a deprotonative cross-coupling process

Chemo- and regioselective C(sp³)-H arylation of unactivated allylarenes via a deprotonative cross-coupling process