Analysis of illicit drugs such as amphetamines is usually done by chromatographic methods like gas chromatography (GC) and liquid chromatography (LC). However, even with the advent of LC-MS and GC-MS, sampling pretreatment still plays a very important role in drug analysis. Solid phase extraction (SPE) materials aim to capture illicit drugs and their metabolites in complex samples like urine were developed and have become commercially available to improve drug analysis. Molecularly imprinted polymers (MIPs) are among these materials and they are a class of polymer-based recognition elements tailored to target a specific chemical or a class of structurally related chemicals. In this study, two commercially available MIPs were used in extracting amphetamine from synthetic urine and compared with another commercially available SPE material. The analysis was done using GC-MS and LC-MS. Results showed higher recovery of amphetamines in the MIPs in comparison to the SPE material.

Solid phase extraction of amphetamines using different commercial sorbents

247th National Meeting (2014)

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