Nitric Oxide, produced naturally in the body, has various applications including wound healing and organ preservation. Because of stability, spontaneous generation of NO under physiological conditions and varying release kinetics, diazeniumdiolates are the most applicable NO donor molecule. The discovery of the diazeniumdiolates, or NONOates, by Drago and Paulik, show an advantage of delivering systems; one NONOate releases two NO equivalents under physiological conditions triggered by water, buffer, or thermodynamic processes.Metal Organic Frameworks, which have large pores and good surface solid storage deliveries for gases, are also advantageous to the delivery system. To couple NONOate advantages with the MOF advantages would provide a controllable release mechanism for wound healing and organ preservation and thereby expand the biomedical applications of all healing. Using CuTDPAT MOF, also called 2,4,6-tris(3,5-dicarboxylphenylamino)-1,3,5-triazine, a linker will be created. This linker, , has secondary amines to allow for NONOate formation(Figure 1). From this linker structure, the NONOate can be controllably released in physiological conditions at the desired location without destroying the MOF structure. The MOF can then be reconstructed for more NO loading. With the NO loaded MOF structures, calculations of NO release will be conducted. Using ATR-FTIR and SEM, data will be collected for analysis. Electrospinning the MOF structure in various solutions as well as the linker in separate solution will also be attempted for possible applications.

Using diazeniumdiolates in metal organic frameworks to store and deliver NO

247th National Meeting (2014)

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