We demonstrated a novel method to fabricate individually addressable �micro-bubble� constructions by confining dissolution of a polystyrene prelayer in the polystyrene-silk fibroin multilayer thin film which was patterned to specific shape and dimension by photolithography. Raman spectra revealed that the polystyrene only presented in the self-formed �micro-bubble� region, indicating the successfully �self-encapsulation� property of the �micro-bubble� structures. The count and shape of �micro-bubbles� on each silk fibroin pattern can be well controlled by the pattern thickness and geometry. Furthermore, The silk fibroin pattern with �micro-bubble� constructions also indicated the capability for �self-encapsulation� for various materials, such as hydrophobic and hydrophilic polymers, nanoparticles, which provided a novel method for the application in the field of solid-state delivery system, drug delivery and bioengineering.

Programmed micro-bubble constructions within patterned silk film for encapsulation

247th National Meeting (2014)

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