Synthetic efforts towards an efficient synthesis of the C26�C40 northern hemisphere of spirastrellolide B is reported.  Spirastrellolide B is a member of the bioactive spirastrellolide family of polyketides possessing unique molecular architecture and represents a daunting synthetic challenge.  Currently, a number of reports detailing routes to this Northern Hemisphere exist in the literature.  A synthetic strategy employing a newly crafted Mukaiyama aldol/relay cross metathesis protocol in conjunction with a phosphate-mediated desymmetrization method will be discussed.

Synthetic efforts towards the synthesis of the C26�C40 northern hemisphere of spirastrellolide B

247th National Meeting (2014)

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