In the progress of decarboxylative allylation reactions it is a great interest to activate allylic alcohols in situ to obtain pi-allyl palladium intermediates instead of using pre-synthesized allyl carbonates. Due to the inherently poor leaving ability of the hydroxyl group several attempts to activate allyl alcohols have been made using Lewis acids such as Ti(OPri)4, BEt3, BPh3, and SnCl2. Compared to these attempts to activate allylic alcohols, CO2 is an economical choice, being an inexpensive and a readily available gas. CO2 activates the allylic alcohol in 2-(1-hydroxyallyl)phenol substrates allowing cyclization of pi-allyl palladium intermediates to synthesize benzopyrans. Further we report a successful attempt to activate allyl alcohols by an adjacent silyl group to obtain benzopyrans.

Palladium catalyzed decarboxylative cyclizations via CO<sub>2 </sub>and silyl activation

247th National Meeting (2014)

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Palladium catalyzed decarboxylative cyclizations via CO2 and silyl activation

Palladium catalyzed decarboxylative cyclizations via CO₂and silyl activation