A convenient and efficient procedure is described for the sulfamoylation of alcohols using various modified 'Burgess type' reagents (1). The ambient temperature stable reagent 1 reacts with phenols as well as primary and secondary alcohols to give high to modest yields. The relative reaction rate of substrates was determined (primary>phenol>secondary>>tertiary). The reagent's utility as a selective sulfamoylation reagent with polyols is also demonstrated.

Modified "Burgess type reagent": A convenient sulfamoylation reagent for alcohols

247th National Meeting (2014)

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