Several problems are associated with use of biological systems in studying drug metabolism.� In vitro studies produce small quantities of primary metabolites that are hydrophilic and difficult to isolate.� Animals studies necessitate sacrifice of animals and are expensive. Liver slice preparations of variable potency make it difficult to quantitate oxidant stoichiometry.� Many metabolites are not amenable to synthesis by conventional routes.We present examples of porphyrin-mediated oxidations of sophisticated pharmaceutical entities. The reactions are generally applicable and have been used on numerous substrates. This is an efficient method for the systematic identification of the entire spectrum of metabolites.Our proprietary in vitro chemical technology (�synthetic livers�) allows us to mimic the in vivometabolism of chemical entities used in pharmaceuticals, cosmetics, polymers, agricultural and synthetic dyes. Biomimiks� enables prediction of metabolism patterns, pathways and profiles and introduces a new paradigm for drug discovery and mimicking drug-drug interactions for clinical diagnostics.

Chemosynthetic livers: A new paradigm for drug discovery

247th National Meeting (2014)

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