Peptides that recapitulate the structural and functional properties of proteins serve as models of complex biological systems, as building blocks for synthetic biology, and as a privileged class of nanostructures. However, to mitigate the material properties of these peptides, we conjugate synthetic polymers (i.e., dendrons) to minimalist peptide models of proteins. Understanding how synthetic groups affect the structure of the peptides is desirable for the design of hybrid biomaterials for nanomedicine. Our approach to developing this understanding involves critically testing rules for the de novo design of peptides that mimic protein folding and assembly in the context of dendron-peptide conjugates. The presentation will illustrate spectroscopic and biophysical studies to systematically evaluate how robust are these protein design rules.

Translating de novo protein design rules for hybrid biomaterials

247th National Meeting (2014)

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