The current state-of-the-art liquid chromatography stationary phase materials are produced by bonding chloro- or methoxysilanes to surface hydroxyls of highly porous silica solid supports. A promising gas-phase deposition technique, coined Functionalized Carboxylate Deposition (FCD), was used to rapidly deposit a self-assembled monolayer of targeted a-carbon modified carboxylic acid containing small molecules to porous silica solid supports. The FCD process rapidly (15-30 min) produced novel stationary phases, including a stationary phase coined: Halophase. Halophase showed interesting properties, including the ability to tune retention characteristics of the stationary phase depending on the identity of the halogen.

Halophase: A novel stationary phase with tunable retention properties through functionalized carboxylate deposition of halogenated small molecules

247th National Meeting (2014)

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