There is strong interest in radioactive 166holmium nanoparticles in radiation therapy for the treatment of cancer. The preparation of lipid coated/uncoated platinum drug loaded 165holmium iron garnet magnetic nanoparticles will be described. These nanoparticles were explored as a carrier material for the stable isotope 165Ho and, after neutron capture, its subsequent therapeutic radionuclide, 166Ho (half-life, 26.8 h), for use in radionuclide therapy of cancer. The initial materials were characterized using PXRD, SEM, EDX, TEM, ICP-MS, Zeta potential measurements and neutron activation. Stability, dilution studies and cells studies of neutron activated lipid coated/uncoated platinum drug loaded nanoparticles confirm the biocompatibility of the prepared materials.

Platinum drug loaded holmium iron garnet nanoparticles enhance combination chemotherapy and radiation therapy

247th National Meeting (2014)

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