Ionic liquids have found many applications in electrochemical sensors due to their intrinsic ionic conductivity and electrochemical stability over wide potential window. In particular, ionic liquids were found to maintain the bioactivity of enzymes, which makes them ideally suited for the development of biosensors. In this talk, we present that a stable molten salt of a quantum-sized gold nanocluster can be prepared by ion-pairing of a Au25 nanocluster protected with (3-mercaptopropyl)sulfonate with imidazolium cation, 1-decyl-3-methylimidazolium, and its application for the detection of glucose based on its unique electrochemical and biocompatible properties. To prepare electrochemical sensor, the glucose oxidase (GOx) was immobilized in the molten salt, which was subsequently cast on a glassy carbon electrode to form modified electrodes. Cyclic voltammograms of the modified electrode exhibited well-defined and reversible redox peaks corresponding to Au250/1- and Au25+1/0. The electrochemical sensor showed dramatic enhancements in both anodic and cathodic peak currents upon the addition of glucose, indicating the electrocatalytic activity of Au25 nanocluster. In addition, GOx immobilized in the molten salt exhibited higher biological activity, demonstrating that the Au25 ionic liquid acts as an excellent support for the enzymatic reaction of GOx.

Electrochemical glucose sensors based on an ionic liquid of Au<sub>25</sub> nanocluster

247th National Meeting (2014)

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Electrochemical glucose sensors based on an ionic liquid of Au25 nanocluster

Electrochemical glucose sensors based on an ionic liquid of Au₂₅ nanocluster