Among many distinct nanomaterials, plasmonic metal nanoparticles are very prolific in literature, mainly due to their fascinating optical properties. Importantly, the NIR activity of plasmonic materials such gold nanoprisms (NPRs) makes them very useful materials for many relevant applications in vivo such as photothermal therapy and optoacoustic imaging, among others. In vitro studies are however a priority in order to assess their biosafety. Herein, we report a multiparametric investigation on the impact of surface modified NPRs on mice and human primary and transform cell lines. Upon exposure of NPRs to cells, and following uptake, most important parameters such as generation of reactive oxygen species (ROS), mitochondrial hyperpolarization, proliferation, cell morphology and apoptosis features were systematically assayed. Results clearly demonstrate a significant impact of the internalized NPRs in the cell morphology and mitochondria, which however do not translate into impartment of cell viability. Under NIR illumination, these nanoprobes can cause apoptosis. Herein, molecular details following photothermal therapy are described.

Insights into the cellular response following photothermal therapy

247th National Meeting (2014)

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