In this work, we have prepared nanoassemblies comprised of the polyphenols such as gallic acid conjugated with a series of natural polyamines. The goal of this work was to develop a new family of nanoassemblies with potent antioxidant properties. It was observed that the assembly process was dependent upon not only the type of polyphenol utilized but also the length of the polyamine moiety. While short chained polyamine moieties mostly yielded a mix of fibers and vesicular structures, larger polyamine chains tended to form fibrillar structures. The growth was monitored over a period of two weeks by both dynamic light scattering as well as by turbidity measurements. We also examined the thermal properties of the assemblies by differential scanning calorimetry. Radical scavenging assays were conducted by standard DPPH as well as FRAP assays at varying concentrations of the nanoassemblies. Furthermore, we also examined the antimicrobial properties of the formed nanoassemblies by examining the inhibition of growth of the fungus rhizopus.

Self-assembly and growth of new polyamine-polyphenol conjugates for biological applications

247th National Meeting (2014)

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