Quorum sensing, a method of communication between gram-negative bacteria, has been widely studied in pathogenic bacteria. These bacteria produce acyl homoserine lactones (AHLs), which are released into the surrounding environment and released into the surrounding environment. In addition to signaling between bacteria, these quorum sensing molecules can provoke an anti-inflammatory response in mammalian cells. However, mammalian cells produce paraoxonases that are capable of hydrolyzing AHL molecules. As inflammatory bowel disease is caused by an inappropriate inflammatory response in the intestine to intestinal bacteria, this report aims to study the interactions between AHLs and intestinal cells. The results show that although the AHLs are not taken into or transformed by the intestinal cells HT29, the presence of the cells prevents the transformation into tetramic acid.

Acyl-homoserine lactones: Uptake and transformation by intestinal cells

247th National Meeting (2014)

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