In collaboration with experimentalists, we study the self-assembly of PEGylated dendron-basedcopolymers (PDCs) with different end-groups functionalities (-OMe, -NH2, -COOH, and -Ac) intodendron micelles. We use classical molecular dynamics simulations to model these systems to comparethe morphologies of PDC micelles with PEGylated linear copolymers micelles, and analyze the effects ofthe monomer architecture on the micelle size, aggregation number, and structure of its individualregions1,2. We also investigate how different PDC micelles with charged end groups interact with lipidbilayer membranes to figure out under which conditions the micelles enter into cellular systems. Finally,we study the interactions of mixed PDC micelles with membrane proteins. The highly stable PDCmicelles have a great potential to provide novel drug delivery platforms.1. J. W. Bae, R. M. Pearson, N. Patra, S. Sunoqrot, L. Vukovic, P. Kr�l, and S. Hong. Chem. Comm. 47, 10302(2011).2. R. M. Pearson, N. Patra, H.-J. Hsu, S. Uddin, P. Kr�l, and S. Hong. ACS Macro Lett. 2, 77 (2013).

Dendron-based PEGylated micelles: Structure, stability and interactions with lipid membranes

247th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.