Emetine, an isoquinoline alkaloid from the ipecac species, has shown interesting medicinal properties including anti-cancer, anti-viral and anti-parasitic activities. In efforts to improve the pharmacological properties associated with emetine, we are exploring chemical modification of the N-2' position of emetine to compounds with improved efficacy but reduced host toxicity. A series of novel dithiocarbamate ester derivatives were synthesized in our research group for evaluation in some cancer cell lines. Using COSY, HETCOR and DEPT-NMR experiments, this paper presents detailed 1H and 13C NMR characterization of some dithiocarbamate ester derivatives of emetine.

Synthesis, <sup>1</sup>H- and <sup>13</sup>C- NMR  spectroscopic studies of some novel emetine dithiocarbamate ester derivatives

247th National Meeting (2014)

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Synthesis, 1H- and 13C- NMR spectroscopic studies of some novel emetine dithiocarbamate ester derivatives

Synthesis, ¹H- and ¹³C- NMR spectroscopic studies of some novel emetine dithiocarbamate ester derivatives