Diacylglycerol acyltransferase1 (DGAT1) catalyzes the final step in triglyceride biosynthesis and have been identified as potential therapeutic target for human obesity and type 2 diabetes. We identified a series of biarylcinnamamide derivatives as potent DGAT1 inhibitors. In this presentation, we will discuss synthetic method, the structure-activity relationship (SAR) of this series and our findings with DMPK profile and significant efficacy in obesity models.

Synthesis and structure-activity relationship of novel biarylcinnamamide derivatives as potent DGAT1 inhibitors

247th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.