Many biological functions depend on multiple, simultaneous interactions between ligands and receptors at the surfaces of cells.  The term multivalency describes these binding events.  Studying multivalent interactions at the cell surface is challenging because current analytical methods provide only modest insight into the details of these complex binding interactions.  We have developed a new type of multivalent scaffold that is highly programmable and very versatile.  Using ligand-modified peptide nucleic acids (L-PNAs) in conjunction with different series of complementary oligonucleotides, multivalent libraries can be readily generated that completely control ligand location, spacing, and valency.  The application of our technique to study the multivalent arrangement of two membrane receptors will be presented.

Versatile multivalent display system to investigate membrane receptor interactions

247th National Meeting (2014)

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