Secondary chloroformate esters have wide commercial use as intermediates in pesticides, medicines, food preservatives, and other related chemical products. The steroid industry primarily uses cyclohexyl chloroformate in the production of hydroxylated steroids. In this undergraduate research project the specific rates of solvolysis of cyclohexyl chloroformate have been measured in several pure and binary aqueous organic solvents, including in some fluoroalcohol mixtures. The kinetic rates for this cyclic chloroformate were obtained using acid-base titrations with lacmoid as an indicator. Quantitative measures were widely explored and thoroughly investigated to understand and to provide convincing evidence for the effects of solvent variation on rates of reaction.

Evaluation of solvent effects in cyclohexyl chloroformate solvolysis

247th National Meeting (2014)

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