The thyroid hormone (TH) regulates many physiological functions in vertebrates including the cardiovascular system, metabolism, brain development, and growth. A person suffering from a thyroid disorder can experience symptoms in these areas, and if left untreated, only get worse. Unfortunately, there are limited treatment options because thyroid hormone biology is not completely understood. Recent research has shown that T1AM, a compound found in various tissues throughout the body, may play a role in thyroid hormone regulation. T1AM acts on the Trace Amine Associated Receptor (TAAR). TAAR activation leads to physiological effects in opposition to those induced by TH. The goal of this project is to develop novel T1AM derivatives to better understand the role of TAAR and T1AM in TH biology. Specifically, these compounds will incorporate an extra phenyl ring and based on previous work may be antagonists for TAAR. Selective regulators for TAAR will be valuable biological tools.

Novel biphenyl ureas as regulators of the trace amine associated receptor

247th National Meeting (2014)

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