Heterocycles have continued to be the focus of intense synthetic activity both in academia and industry. Over 75% of the top 200 brand name drugs are heterocycles or contain heterocycle subunit. Heterocycles also account for more than 50% of all known organic compounds. Rhodium catalyzed carbon carbon bond formation is very valuable in forming the carbon skeletons of complex heterocycle synthesis. Rhodium catalyzed carbon carbon bond formation reactions using arylboronic acid/organometallic reagents in 4-quinolones and O-heterocycles such as benzopyrans have been developed. We are also interested in applying this new C-C bond formation strategy to the synthesis of bisteppogenin from flavonoids and biflavonoids family, one of the most abundant classes of plant constituents, known for their rich biological/pharmacological activities including anticancer, antibacterial, antiviral, anti-inflammatory and immunomodulatory activities.

Development of rhodium catalyzed carbon-carbon bond formation and application to the synthesis of bisteppogenin

247th National Meeting (2014)

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