Acetylcholine is an important neurotransmitter in humans, and thus the regulation of acetylcholine levels has many therapeutic applications. The acetylcholine esterase (AChE) enzyme is one key to acetylcholine regulation, and much work has been done to prepare compounds that inhibit this enzyme. We present the synthesis of a group of potential AChE inhibitors predicated on the coupling of N-benzyl nipecotic and isonipecotic acids with an assortment of amines. Structural variation is also added by reducing the amide that results from the coupling reaction.

Synthesis and characterization of <i>N</i>-benzyl nipecotate and isonipecotate derivatives as potential acetylcholine esterase inhibitors

247th National Meeting (2014)

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Synthesis and characterization of N-benzyl nipecotate and isonipecotate derivatives as potential acetylcholine esterase inhibitors