Tumorous cancer cells have shown to have elevated levels of polyamine transport systems attached to the cell surface versus normal cells.  In order to maintain an effective drug delivery system, we aim to attach polyamines to the nucleic acid base (nucleobase) guanosine.   Guanosine is a bicompatible nucleobase that can form in a g-quartet system, a tightly packed structure that results in significant hydrogel formation when numerous quartets form quadruplexes.  Replacing the hydrogen on the 8-position of guanosine with an aromatic ring will stabilize the g-quartet/quadruplex systems and add potency to the molecules.  The 5'-position of guanosine will be used as the selective attachment point for a variety of polyamines.  The development of this drug delivery system will allow for the guanosine compound to specifically target cancer cells with polyamines transport systems on the surface in order to deliver the proper drug.

Drug delivery systems utilizing modified nucleobase hydrogelators and polyamines

247th National Meeting (2014)

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