Two new linear gold(I) complexes of formulae [Au{P(t-Bu)3}(S2CN(CH3)2)] (1  ), and [Au{P(t-Bu)3}(S2CN(C2H5)2)] (2  ) have been prepared by the reaction of equimolar amounts of [Au{P(t-Bu)3}(Cl)] with sodium dimethyldithiocarbamate monohydrate, and sodium diethyldithiocarbamate trihydrate respectively. The complex (1  ) crystallizes in monoclinic space group while the complex (2  ) crystallizes in orthorhombic space group. IR spectroscopy confirms the presence of thioureide bond (R2N-CS2) in the complexes (1)  and (2)  . The 1H, 13C and 31P NMR, and IR spectra of the Au(I) complexes (1)  and (2)  corroborate with their single crystal X-ray structure analyses. These gold(I) dithiocarbamate complexes show selective and promising in vitro cytotoxic activities against A549 (human lung carcinoma), HeLa (human cervical cancer) and MCF7 (human breast cancer) cell lines.The author(s) would like to acknowledge the support provided by King Abdulaziz City for Science and Technology (KACST) through the Science & Technology Unit at King Fahd University of Petroleum & Minerals (KFUPM) for funding this work through project No. 11-MED1670-04  as part of the National Science, Technology and Innovation Plan.

New gold(I) complexes with t-butyl phosphine and dialkyl dithiocarbamate ligands: Synthesis, spectroscopic characterization, crystal structure determination, and in vitro cytotoxic evaluation against A549, HeLa, and MCF7 human cancer lines

247th National Meeting (2014)

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