A series of C2-symmetric platinum complexes of the type Pt(biox')Cl2 (biox' = R,R- or S,S-4,4'-R2-2,2'-bioxazoline, where R = -H, -Me, -iPr, -Ph, -Bz) were synthesized in quantitative yield from [PtCl2]n and 2,2'-bioxazoline in methanol and the cytotoxicity of these compounds was tested in P388 and L1210 murine leukemia cell lines using the MTT assay. We have found that these complexes have lower activity against P388 (6.25 �M < IC50 < 100 �M) than against L1210 (8.3 �M < IC50 < 150 �M) and that the S,S isomers show higher activity overall than the R,R-isomers. The impact of stereochemistry and steric effects on the structure of the presumed adducts and their resulting cytotoxicity will be discussed.

Cytotoxicity of C<sub>2</sub>-symmetric platinum(II) bioxazoline complexes in murine leukemia (P388, L1210) models

247th National Meeting (2014)

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Cytotoxicity of C2-symmetric platinum(II) bioxazoline complexes in murine leukemia (P388, L1210) models

Cytotoxicity of C₂-symmetric platinum(II) bioxazoline complexes in murine leukemia (P388, L1210) models