A new series of synthetic protein transduction domain mimics (PTDMs) was designed to analyze the importance of segregation along the backbone of guanidine and phenyl groups on their membrane interaction and cellular internalization abilities.  The structure-activity relationships were evaluated by both a biophysical assay, using dye-loaded vesicles, and by in vitro cellular uptake studies of fluorescently labeled chains into Jurkat T cells.  The results showed that functional group segregation impacts activity. This study gives new design guidelines for the development of PTDMs. 

Building synthetic mimics of naturally occurring proteins

247th National Meeting (2014)

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