Pd(II)-catalyzed enantioselective and position-selective C�H activation reactions are developed using mono-N-protected chiral amino acid ligands. C�H activation intermediates are characterized, offering insights into the origin of the observed stereoselectivity. Most importantly, these chiral ligands are found to accelerate drastically C�H activation reactions, shortening the reaction time from two days to 20 minutes.

Ligand-accelerated C-H activation reactions: New synthetic disconnections

247th National Meeting (2014)

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