We present the synthesis of a poly(lactic acid)-graft-poly(ethylene glycol) copolymer.  To obtain a polymer with one poly(ethylene glycol) (PEG) chain per monomer unit, a thiol-functional PEG chain was attached to an alkene lactide monomer through radical thiol-ene chemistry. The resulting lactide derivative was polymerized via ring-opening polymerization using 1,5,7-triazabicyclo[4.4.0]dec-5-ene as organocatalyst. The polymer furthermore contains functional handles on the PEG chain ends to attach biorelevant groups such as peptides or fluorescent dyes through a modular synthesis strategy.  

Synthesis of poly(lactic acid)-<i>graft</i>-poly(ethylene glycol) for biomedical applications

247th National Meeting (2014)

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Synthesis of poly(lactic acid)-graft-poly(ethylene glycol) for biomedical applications