Alzheimer's disease (AD) is a growing and costly worldwide problem. This research focuses on the specific impact of amyloid-� (A�) peptides on AD etiology. In the presence of certain interfaces such as gangliosides and other lipid head groups, A� peptides reorganize into individual unstable �-sheets and aggregate to form oligomeric and fibrillogenic species. In this research, a polymeric mimic of phosphatidylserine, an anionic phospholipid, will be synthesized so that evaluation of its impact on A� conformational change and aggregation can be done in the future. Specifically, the monomer 2-acryl amidoethyl dihydrogen phosphate (AAEP) was synthesized and then polymerized using aqueous RAFT polymerization. The monomer was characterized using 1H NMR to verify the structure, FT-IR to confirm the presence of the phosphate moiety, and ESI to determine the molecular weight. The homopolymer was characterized using 1H and 13C NMR to determine the chemical structure and ASEC-MALLS to determine the molecular weight.

Synthesis of poly(2-acryl amidoethyl dihydrogen phosphate) as a phospholipid polymer mimic for the study of amyloid-� peptide aggregation

247th National Meeting (2014)

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