Despite the increasing number of such agents reported, gadolinium and particulate-based responsive contrast agents for MRI have found limited practical use in biomedical and clinical research due to their limited response, the interference of physiological anions, and most importantly, due to their inability to distinguish a change in signal intensity due to the presence of the targeted analyte from those resulting from variations in local concentration of the contrast agent. Herein we present a new class of responsive MRI contrast agents based on the Lanthanide Induced Shift (LIS) and Paramagnetic Relaxation Enhancement (PRE) of two 19fluorine signals of a same complex modulated by binding or reaction with a targeted analyte. The advantages and limitations of 19---F-LIS responsive contrast agents over their Gd and MION analogues will be highlighted in a case study focusing on imaging copper, a metal involved in the neurodegenerative Alzheimer's disease.

Paramagnetic fluorine-based responsive MRI contrast agents

247th National Meeting (2014)

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