There has been increasing interest in the development of hybrid systems with readily tunable properties to afford a myriad of materials with unique physiochemical features. For instance mixed polymeric micelles �hybrid systems prepared from the coassembly of polymer amphiphiles exhibiting distinct chemical properties- find multiple applications in the field of drug delivery and targeting. Here we report on the formation of hybrid nanoparticles from architecturally distinct block copolymer amphiphiles by controlling the molar composition of a blend and the kinetic features of the assembly process. Specifically, we examined and contrasted the co-assembly of linear and linear-dendritic amphiphiles under equilibrium and non-equilibrium conditions. Through careful manipulation of the amphiphile architecture, blend composition and final solvent content, hybrid nanoparticles of controllable size and patchiness could be readily achieved. The stability of hybrid nanoparticles towards protein solutions/serum and red blood cells is subsequently assessed in vitro using FRET, DLS and isothermal titration calorimetry techniques. The results shows that amphiphile architecture plays a significant role on the protein-nanoparticle interactions.

Kinetically arrested assemblies of architecturally distinct block copolymers: Effect of amphiphile on protein-micelles interactions

247th National Meeting (2014)

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