A synthetic method is described for controlled epitaxial growth of Pt on the surface of Fe3O4 nanoparticles, resulting in highly uniform bifunctional electrocatalytic/magnetic nanohybrids with good dispersibility in aqueous solutions. Single-nanoparticle collision events were detected by electrocatalytic amplification using Hg film ultramicroelectrode in the presence of hydrazine redox indicator in neutral buffered aqueous solutions. The application of an external magnetic field leads to an increased frequency of nanohybrid collision events. The Pt-Fe3O4 nanohybrids could potentially serve dual functions as both electrocatalytic probes for real-time sensing of single DNA hybridization events and preconcentration agents for substantially lowering detection limits.

Designer bifunctional nanohybrids for electrochemical biosensors

247th National Meeting (2014)

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