The Oppenauer Oxidation was studied to delineate a green protocol for the oxidation of aromatic secondary alcohols under mild conditions. Acetone, cyclohexanone, and pivaldehyde were used as oxidizing agents, with hydrous zirconia catalysts, to give the desired products in high yields with fast delivery time, minimal downstream processing, and reduced aldol side product condensation in an inexpensive sustainable process.  Cerium oxide supported low-level palladium perovskite catalysts were used in flow reactors for Sonogashira cross coupling reactions.  Products were delivered with high yield and fast delivery times using cheap reagents, mild conditions, and extremely low-levels of palladium loading.  This novel flow procedure offers the advantages of reduced downstream processing, containment of the heterogeneous catalyst, and the potential for reuse of perovskite catalysts without the loss of catalytic activity.

Oppenauer oxidation using hydrous zirconia catalysts and cerium oxide enhanced Sonogashira reactions in flow by low-level palladium perovskite catalysts

247th National Meeting (2014)

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