Dynamic chemistry bonds contain both non-covalent bonds and reversible covalent bonds. Dynamic-covalent chemistry often relates to the reversible covalent bonds. Dynamic covalent bond could cleave and reform easily under the specific conditions. The exchange between cleavage and formation of the dynamic covalent bond is in a conditional equilibrium. For the past few years, dynamic-covalent chemistry and multiple weak interactions are introduced to the polymer systems and various dynamic systems are developed.Combining dynamic-covalent bond with supramolecular chemistry, our group has explored the multiple stimuli responsive macromolecular systems. Through modulating the supramolecular moieties and homopolymer composition, we developed new block copolymers and polymer networks based on dynamic chemistry. In solution, they can fabricate into stimuli-responsive smart nanoassemblies, and we can realize their reversible self-assembly and disassembly by regulating the external stimuli sources. Recently, we have designed a dual responsive hydrogel based on chitosan with hydrophobic interaction and dynamic covalent Schiff-base linkage as crosslinkers. The dynamic hydrogel shows good self-healing ability (Figure 1). In addition, the unique thermo-responsibility and the high strength of the smart hydrogel make it outstanding as carries for drug-controlled release and repair materials.

Dynamic self-assembly and self-healing hydrogel based on dynamic-covalent chemistry

247th National Meeting (2014)

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