Water soluble porphyrin nanoparticles were prepared via self-assembly of Poly (ethylene glycol)-b-polycaprolactone (PEG-b-PCL) conjugated porphyrin copolymer in aqueous solution. The diameters of the nanoparticles were found to be ~ 100 nm as confirmed by Transmission Electron Microscopy (TEM) and Dynamic Laser Scattering (DLS) studies. Furthermore, these nanoparticles showed an increase in fluorescence intensity with increasing PCL molecular weight of the copolymer. These improved photochemical properties could pave the way to enhance porphyrin nanoparticle performance for applications in imaging and photodynamic therapy.

Synthesis and characterization of photo-active amphiphilic porphyrin/poly(ethylene glycol)-b-polycaprolactone copolymer nanoparticles

247th National Meeting (2014)

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