A novel all-carbohydrate-based polymer was synthesized through tetrabutyl ammonium iodide (TBAI)-catalyzed polymerization of di-functional AB monomer, 2,3,4-tri-O-acetyl-alpha-D-glucopyranosyl bromide. The polymerization was highly efficient, giving sugar poly(orthoester) with molecular weights up to 6.9 kDa. Nanoparticles were prepared by an emulsion-evaporation-lyophilization procedure using poly(ethylene glycol, Mn = 10 kDa) as an emulsifier, which gave average SEM sizes of 230 � 60 nm. These carbohydrate-based polymers, exhibited excellent biocompatibility with minimal non-specific protein adsorption. Furthermore, with acid-labile orthoester linkages in the polymer backbone, the nanoparticles are highly pH-responsive, allowing fast release of Dexamethasone, which was used as a model drug.

Carbohydrate-based nanodelivery systems

247th National Meeting (2014)

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