Supramolecular peptide nanostructures are attractive for targeted systemic therapies given their potential ability to bind specific receptors or tissue matrix components.  They are also of interest because they would be fully biodegradable and could easily incorporate therapeutic elements in the peptide sequences that form the drug vehicles themselves.  Furthermore, supramolecular design offers the possibility of increasing their half life which could be problematic in the clinical implementation of hundreds of potential peptide drugs.   Given all these attributes they could revolutionize disease treatments with greater efficacy and the elimination of serious side effects.  This lecture describes the development of novel peptide amphiphile filamentous nanostructures that can be targeted to injured arteries following balloon angioplasty and chemically designed to deliver nitric oxide in order to avoid the clinically important problem of restenosis after stent placement.  The lecture will also describe peptide nanostructures that can be targeted to specific receptors expressed in cancer cells while also carrying chemotherapy cargo in their hydrophobic compartments.  Ongoing work toward novel systemic strategies to reverse formation of atherosclerotic plaques with multifunctional peptides will be described as well.

Peptide nanostructures for targeted drug delivery in cardiovascular therapies and cancer

247th National Meeting (2014)

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