Creatine is very well known within the nutrition and fitness industries as a nutritional supplement for increasing muscle size, endurance, and performance. Based on numerous initial studies, creatine has additionally shown an ability of reducing symptoms of neuromuscular and neurodegenerative diseases as well as improving cognitive function and treatment of depression. Di-creatine citrate and tri-creatine citrate salt derivatives of creatine monohydrate, were synthesized using citric acid in combination with creatine monohydrate under various conditions to maximize yields. NMR (Nuclear Magnetic Resonance) was used along with elemental analysis to confirm the chemical formulas of the synthesized compounds. A kinetic degradation study of the synthesized creatine salts was conducted using NMR .The solubility of each compound was determined and compared to that of creatine monohydrate to determine the usefulness of the synthesized products. The effect of pH and temperature on the degradation of the creatine salts was also examined.

Kinetic and solubility analysis comparing di-creatine citrate and tri-creatine citrate to creatine-monohydrate

247th National Meeting (2014)

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