Inflammation is a patho-physiological response of the body to tissue/cell damage by pathogens, chemicals and physical injury.  Acute inflammation is a short-term response mediated by leukocytes that works by removal of the stimuli and repairing the tissue while chronic inflammation associated with disease conditions such as allergies, arthritis, autoimmune responses is a prolong, maladaptive response that results in tissue destruction. Resveratrol (3,5,4-trihydroxy-trans-stilbene), a phytoalexin primarily present in red grapes has antioxidant and anti-in?ammatory activities. Present study aims to evaluate the role of resveratrol and its potent analogs MC4 and MR4, to inhibit TPA-induced inflammation in NFKB-Jurkat GFP (NJG) reporter assay cell line. Fluorescent microscopy and quantitative analysis of GFP signal (a function of TPA of induced NFKB activation) clearly shows a significant decrease in GFP signal in presence of resveratrol indicating an inhibitory role in NFKB-activation. In conclusion, the anti-inflammatory role of Resveratrol (10uM), MC4 (10nM) & MR4 (1uM) is possible mediated via downregulation of NFKB, a pivotal transcription factor in the inflammatory pathway.

Effect of potent analogs of resveratrol, MC4 and MR4 in inflammation

247th National Meeting (2014)

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