A new class of isatin  schiff bases were synthesized and fully characterized.  The synthesized schiff bases showed a good activity against Maximum Electroshock (MES) and Subcutaneous Metrazole  (ScMet) . The LD50 value was obtained for all the series of schiff bases. The structural changes in the Schiff bases  led to the synthesis of lead molecules which showed a broad spectrum of anticonvulsant activity without no neurotoxicity at stipulated does and thus can be used as a prototype for the development of anticonvulsant drug. This presentation will focus on  the synthesis of new series of isatin Schiff bases, their  anticonvulsant property as well their comparison to present existing drug.

Isatin Schiff bases with a broad range of anticonvulsant property

247th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.