The interface between supramolecular chemistry and transition metal catalysis has received surprisingly little attention in contrast to the individual disciplines. It provides, however, novel and elegant strategies that lead to new tools for the search of effective catalysts, 1 and as such this has been an important research theme in our laboratories. In this presentation I will focus on supramolecular strategies to control selectivty in transition metal catalysis, which is especially important for reactions that are impossible to control using traditional catalyst development. For substrates with functional groups we use substrate orientation effects to control selectivty, whereas for non-functionalized substrates we create cages around the active transition metal. Next to supramolecular control, supramolecular approaches appear ideally suited for the creation of large ligand libraries. The large number of catalyst that become available in this manner, asks for screening strategies and evolutionary approaches. A first academic example of catalyst selection from a mixture will be discussed. In addition, the application of a cofactor strategy will be presented, which is also ideally suited for selection procedures. In addition to the new concepts I will also show some examples in which we use these strategy in synthesis References:  a)  JNH , Reek et al  Org.  Biol. Chem., 3, 2005 ,  2371; 1b) Chem. Eur. J., 2006 , 12, 4219; 1c) J. Am. Chem. Soc. 2006 , 128, 11344; 1d) Chem. Commun. 2006  4679. 1e) Dalton. Trans 2006,  2308; 1f) Angew. Chem. Int. Ed. 2006 , 45, 1223; 1g) Angew. Chem. Int. Ed. 2008 ; 1h) J. Am. Chem. Soc. 2009  131, Angew. Chem. Int. Ed. 2009 ; Angew. Chem. Int. Ed. 2011,  7342;Angew. Chem. Int. Ed. 2011 , 396;Nature Chemistry2010 , 615;  Nature Chemistry2010,  417.1f)J. Am. Chem. Soc. 2011 , 17176; J. Am. Chem. Soc. 2012.  1260.

Supramolecular strategies in transition metal catalysis

247th National Meeting (2014)

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