We have designed new vesicle forming, amphiphilic diblock copolypeptides that contain multiple levels of functionality within their hydrophilic domains. Aside from providing water solubility, hydrophilic segments have been developed to assist in cell binding, cell uptake, and to promote intracellular vesicle disruption for cargo release. By employing new synthetic methods, unprecedented levels of functionality can be programmed into these materials. We report on the self-assembly of these vesicles and analysis of their cell uptake, minimal cytotoxicity, and intracellular disruption. We will describe how polypeptide design can be used to control interactions between the polypeptide assemblies and the cells and tissues relevant for therapeutic delivery applications.

Enzyme responsive block copolypeptide vesicles for therapeutic delivery

247th National Meeting (2014)

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