Linear polymer from ring-opening metathesis polymerization can be facilely functionalized by allyl groups, and intramoleculerly crosslinked by ring-closing matethesis to yield single-chain polymer particles controllably with valency control. The particles serve as excellent carriers as functionalities of interest can be loaded in any stage during synthesis, and the particles themselves can be tuned water-soluble through dihydroxylation. Wide application of such particles can be anticipated. For example, the particles showed to be excellent protective carriers for unstable fluorophores such as Fluorescein. Aminated particles showed capability of gene delivery. Dihydroxylated particles can serve as templates for metal nanoparticle formation. We are still actively searching for the capabilities of this material in light harvesting and antimicrobial fields.

Synthesis and application of single-chain polymer nanoparticles from a consecutive ROMP-RCM process

247th National Meeting (2014)

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