The synthesis and characterization of multi-functionalized Fe3O4/SiO2 core-shell magnetic nanoparticles were investigated. The magnetic nanoparticles were prepared by two methods, namely microemulsion and direct-coprecipitation of Fe(III) and Fe(II) salts. Both of the methods generated well-dispersed and mono-distributed magnetic nanoparticles. The direct-coprecipitation of iron salts strategy generated core-shell structure superparamagnetic nanoparticles with a high saturation magnetization of 55.6 emu/g under mild conditions. The surface-initiated reversible addition fragmentation chain transfer (RAFT) polymerization of methylacrylic acid was conducted on CPDB coated magnetic nanoparticles and the resulting nanoparticles are water soluble. TEM images showed that the poly(methacrylic acid) grafted magnetic nanoparticles were well dispersed with diameters of the individual nanoparticles ~ 40 - 50 nm. The grafted PMAA was methylated by trimethylsilyldiazomethane to conduct organic phase GPC characterization. The PMAA grafted Fe3O4/SiO2 magnetic nanoparticles can enhance the bioactivity of Penicillin G over bacteria (both Gram negative and Gram positive) when physically binding with Penicillin G. 

Synthesis and characterization of water soluble multi-functionalized magnetic nanoparticles via RAFT polymerization

247th National Meeting (2014)

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