Spleen tyrosine kinase (Syk) is an attractive drug target in autoimmune, inflammatory, and oncology disease indications. The most advanced Syk inhibitor, fostamatinb (prodrug of R406), has shown  efficacy in multiple therapeutic indications but  its clinical progress has been hampered by dose-limiting adverse effects that have been attributed, at least in part, to the off target activities of R406.  It is expected that a more selective Syk inhibitor would provide a greater therapeutic window.  Herein we report the discovery and optimization of a novel series of imidazo[1,2-a]pyrazine Syk inhibitors. This work culminated in the identification of GS-9973, a highly selective and orally efficacious Syk inhibitor which is currently undergoing clinical evaluation for autoimmune and oncology indications.

Discovery of GS-9973: A selective and orally efficacious inhibitor of spleen tyrosine kinase (Syk)

247th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.